Differentation Makes All The Difference

Optimizing the Wnt signaling pathway to generate elements of healthier skin

Stem cell differentiative decisions are regulated by the Wnt signaling pathway 

Wnt signaling controls whether stem cells remain dormant, proliferate and divide to form new stem cells, or differentiate into new skin cells

  • a central “hub” protein for communication within the Wnt signaling pathway is β-catenin 
  • when beta-cantenin binds to CBP in the nucleus, symmetrical proliferation is favored
  • when beta-catenin binds to p300 in the nucleus, asymmetrical differentiation is favored 
  • Optimal Wnt signaling can help stem-cells regain activities necessary for healthy youthful appearing skin